Diagnostics & Therapeutics

/Diagnostics & Therapeutics

STaRRRT

A Table of Short Tandem Repeats in Regulatory Regions of the Human Genome Tandem repeats (TRs) are unstable regions commonly found within genomes that have consequences for evolution and disease. In humans, polymorphic TRs are known to cause neurodegenerative and neuromuscular disorders as well as being associated with complex diseases such as diabetes and cancer. read more

Regulating uterine contractions

Targeted drug delivery for safer regulation of uterine contractions A common complication of pregnancy and labour is inadequate uterine contractions. Medically induced labour is necessary in a range of situations where the health of the mother and/or baby is a risk. In contrast, the initiation - or increase in intensity or frequency – of uterine read more

Peptide potential for blood, breast cancer

Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer. Whilst remission is achievable in >95% of cases, ~1/3 of patients will relapse and will not survive long-term. The major cause of relapse is drug resistance. Acute myeloid leukemia (AML) is a rapidly progressing blood cancer predominantly affecting older adults, and has the lowest survival read more

Diagnostic biomarkers for peanut allergy

Researchers at the University of Newcastle have identified novel biomarkers that have the ability to diagnose peanut allergy and predict anaphylactic reaction to peanut exposure in allergic individuals. The invention provides an opportunity to develop novel diagnostic methods and protocols to accurately predict reactivity to peanuts based on simple and convenient testing procedures, such as read more

Natural product derived antibacterial

Morbidity and mortality rates for bacterial infections are increasing worldwide mainly due to the development of multiple antibiotic resistance in pathogenic bacteria, costing in excess of $20 billion annually in the US alone. There is particular concern about the growing threat from gram-negative organisms. Due to the alarming increase in the number of antibiotic resistant read more

Novel Therapeutic Solution to Treat Myopia

Globally, uncorrected refractive errors including Myopia are a leading cause of blindness. Researchers at the University of Newcastle have identified novel retinal signals and pathways in the eye that cause ocular expansion and Myopia. This discovery has led to the repurposing of Drug A  and its development as a new therapeutic targeting these novel signals read more

COPD CRO Model

The Priority Research Centre for Asthma and Respiratory Disease (CARD) at the University of Newcastle is a world-class research centre specialising in respiratory medicine and research in the key therapeutic areas of asthma, COPD and recently lung cancer. CARD has developed a novel short term (8 weeks) smoking COPD model that mimics human disease and read more

Novel target and therapy for asthma

Allergic asthma is an inflammatory disease of the conducting airways affecting an estimated 300 million people. There is a particularly high rate of asthma sufferers among children and in developing countries. The proposed therapy targets a novel gene belonging to the tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) activated signalling pathways. The siRNA mediated inhibition of read more

Diagnostics for asthma & COPD

Researchers at the University of Newcastle have developed two novel methods to diagnose and characterise different types of respiratory diseases. A suite of protein markers with excellent diagnostic ability have been identified which facilitate the diagnosis and differentiation of asthma and chronic obstructive pulmonary disease (COPD). Furthermore, a six gene expression biomarker has been identified read more

Novel Amino Acid Supplement Mix

Research investigating endurance athletes performing exercise regimes under controlled conditions has shown that significant quantities of amino acids were lost in sweat. The studies have, for the first time, demonstrated  combinations of these amino acids represent groups of major losses in human and equine sweat that place demands on body resources. Based on the profiles read more